Hyperuricosuria
Also known as: Urate stones
Hereditary
An inherited disorder of uric acid handling that causes high urinary uric acid and a predisposition to urate bladder and kidney stones. It is caused by a mutation in the SLC2A9 gene and is the fixed trait in all Dalmatians, also seen in Bulldogs, Black Russian Terriers and others. Affected dogs are prone to recurrent urate urolithiasis.
Quick facts
- Type:
- Genetic
- Typical onset:
- Chronic
- Body systems:
- Urinary, Metabolic
- Affected species:
- DOG
Breeds at higher risk
These breeds are recorded as more prone to Hyperuricosuria than their species as a whole. Many animals of these breeds never develop it.
- DalmatianHigh risk
Sources & references
- Cornell University CVM — Describes hyperuricosuria as an SLC2A9-related cause of urate stones in dogs.
- OMIA — OMIA phene entry for hyperuricosuria associated with SLC2A9 in dogs.
This content is for educational purposes and is not a substitute for professional veterinary advice. If you are worried about your pet, contact your veterinarian.