Exercise-induced collapse
Hereditary
An inherited disorder in which strenuous exercise triggers episodes of muscle weakness and collapse, classically in Labrador Retrievers and related breeds. It is caused by a mutation in the DNM1 gene affecting nerve transmission during intense activity. Dogs are normal at rest and between episodes, which are usually self-limiting.
Quick facts
- Type:
- Genetic
- Typical onset:
- Acute
- Body systems:
- Nervous, Musculoskeletal
- Affected species:
- DOG
- Reference codes:
- OMIA 001466-9615, OMIA:1466
Sources & references
- Cornell University CVM — Describes exercise-induced collapse as a DNM1-related inherited collapse syndrome of retrievers.
- OMIA — OMIA phene entry for exercise-induced collapse associated with DNM1 in dogs.
This content is for educational purposes and is not a substitute for professional veterinary advice. If you are worried about your pet, contact your veterinarian.