کمبود ارثی فاکتور انعقادی VII که ناشی از جهش در ژن F7 است و معمولاً باعث تمایل خونریزی خفیف میشود. در بیگل و چند نژاد دیگر بهخوبی مستند شده و اغلب بهطور تصادفی در آزمایش انعقاد کشف میشود. اکثر سگهای مبتلا فقط پس از جراحی یا تروما خونریزی میکنند.
Factor VII deficiency is an inherited clotting disorder affecting the extrinsic coagulation pathway. It is typically mild, and many affected dogs never bleed spontaneously.
A recessive mutation in the F7 gene reduces functional factor VII. Beagles are a classic breed, with cases in several others.
Many dogs are asymptomatic. When bleeding occurs it tends to follow surgery, injury or dental procedures, sometimes with bruising or prolonged bleeding.
A prolonged prothrombin time with normal other clotting tests, specific factor VII assay, and a DNA test for the F7 variant confirm the diagnosis.
Significant bleeding is managed with plasma transfusion. Most affected dogs need only awareness and precautions before surgery.
DNA testing of breeding dogs in affected breeds and pre-surgical screening prevent unexpected bleeding and reduce the trait.
This content is for educational purposes and is not a substitute for professional veterinary advice. If you are worried about your pet, contact your veterinarian.
